Early Exposures and Associations with Chronic Disease

This report is a scoping review of evidence for associations between early life environmental exposures and the later development of several of the most  common chronic diseases.

Part One provides context about chronic disease and care in Canada’s aging population, the reality of the multiple determinants of health, the primacy of the social determinants of health, the considerable breadth of environmental influences on health, the importance of early child development to lifelong health, and the scope and complexity of multiple inter-relationships among all these determinants.

Part Two introduces the Developmental Origins of Health and Disease (DOHaD) concept and the related and expanding field of epigenetics. It also discusses key issues that arise in evaluating evidence in complex environmental health issues. The main focus is review of the multiple risk factors for several common chronic diseases (cardiovascular disease, type 2 diabetes, several cancers, asthma, Alzheimer’s disease and Parkinson’s disease) and includes a detailed look at the evidence for links to environmental exposures. Evidence is reviewed for associations between health outcomes and both adult exposures and early life exposures, including in the womb.

Download the report and associated webinar slide decks here:

Early Exposures to Hazardous Pollutants/Chemicals and Associations with Chronic Disease – A Scoping Review

Scoping review of evidence of associations between exposures to hazardous pollutants or chemicals in early life and later life chronic disease. Download full report or executive summary here.

Early Environmental Exposures to Hazardous Pollutants/Chemicals and their Associations with Chronic Disease – Introduction to the Scoping Review

Part One of this series summarizes main findings, context, and trends within two cross-cutting themes: the Developmental Origins of Health and Disease and the Multiple Determinants of Health

Early Environmental Exposures to Hazardous Pollutants/Chemicals and their Associations with Chronic Disease – Focus on Endocrine Disruption and Obesogens

Part 2 in this series recaps the main findings of the study, summarizes the epigenetic/environmental basis of disease, notes implications of endocrine disruption science, and discusses obesity risk factors in the context of emerging science on chemicals suspected as obesogens and diabetogens

Early Environmental Exposures to Hazardous Pollutants/Chemicals and their Associations with Chronic Disease – Policy Implications

Part 3 in this series summarizes the challenges that exist in evaluating scientific evidence of associations between chemical exposures and health outcomes, particularly for endocrine disrupting chemicals and related challenges to existing regulatory approaches.